Glutamine is fuel for the small intestine. Helping you start your research:
GLUTAMINE / GABA = builds up muscle (para-sympathetic Rest and Rejuvenation
Nervous System Runs on GABA - Vagus Nerve).
Prolonged CORTISOL = breaks down muscle (sympathetic Alert, Fight or Flight
Nervous System).
* For the purposes of this page, Glutamine and L-Glutamine are considered the same thing.
Journal Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC5454963/
Glutamine, the most abundant free amino acid in the human body, is a major substrate utilized by intestinal cells. The roles of glutamine in intestinal physiology and management of multiple intestinal diseases have been reported. In gut physiology, glutamine promotes enterocyte proliferation, regulates tight junction proteins, suppresses pro-inflammatory signaling pathways, and protects cells against apoptosis and cellular stresses during normal and pathologic conditions....
Journal Article: https://pmc.ncbi.nlm.nih.gov/articles/PMC4369670/
Mucosal protective factors such as growth factors and nutrients preserve the gut barrier integrity and are beneficial in the treatment of various gastrointestinal diseases. L-Glutamine the most abundant amino acid in blood plays a vital role in the maintenance of mucosal integrity. Glutamine is traditionally termed as a nonessential amino acid, is now considered a
conditionally essential
amino acid. Its consumption in small bowel mucosa exceeds the rate of production during catabolic stress such as trauma, sepsis and post surgery [1, 2]. In the small bowel mucosa, glutamine is an unique nutrient providing fuel for metabolism, regulating cell proliferation, repair and maintaining the gut barrier functions [3]. The focus of this article is on the role of L-glutamine in the preservation of gut barrier function and the epithelial tight junction integrity and gut barrier function...
Journal Article: https://www.sciencedirect.com/science/article/pii/S2213453021000112
Recent research has shown that the amino acid glutamine can positively affect gut health by supporting the gut microbiome, gut mucosal wall integrity, and by modulating inflammatory responses. As modulated by the vagus nerve, via the enteric nervous system, the gut-brain connection can impact the brain's neurochemical environment. Poor gut health can disrupt the balance of neurotransmitters, which can result in neuropsychiatric based conditions such as depression. Glutamine supplementation may provide significant adjunctive nutritional support in cases of depression by promoting proper gut health and function...
Journal Article: https://www.amymyersmd.com/blogs/articles/l-glutamine-benefits
L-Glutamine is one of the most critical amino acids in your body. This powerful amino acid is your body's natural cell builder, yet more importantly, cell rebuilder. However, the benefits of L-Glutamine go beyond your cells. It's needed for brain health, liver and kidney function, metabolic health, and supports heart health.1 Athletes are turning to L-Glutamine to help with muscle recovery since it's needed to build proteins that increase muscle mass. The benefits of L-Glutamine are truly amazing!...
Your body naturally makes L-Glutamine from glutamate and ammonia. This process happens in the muscles, lungs, and liver. While your body does make L-Glutamine on its own, there are circumstances where it becomes a conditionally essential amino acid. These circumstances include chronic stress, increased physical activity such as running a marathon or strenuous exercise, or poor absorption caused by a leaky gut, SIBO, or Candida overgrowth....
~ AmyMyersMD.com
Additional Info. Getting Out of Sympathetic (hyper-alert) Overdrive. DEEP DIVE from 30 minutes to the end with Dr. Scott Sherr. The Energy BluePrint Podcast Your GABA balance. The connections between: Vagus para-sympathetic system > Glutamine (small intestinal healing) > Glutamate > GABA Cycle. Learning to be aware of your GABA balance.
Additional Info. Mitochondrial Optimization. DEEP DIVE with Dr. Scott Sherr and Natalie Niddam. Cordycepin & Methylene Blue: Boost Energy, Focus & Longevity. Synergy of low-doses prevents depeleting the GABA system over time. Methylene Blue as an electron donor and anti-infective at low-dose.
Additional Info. DEEP DIVE from 13:30 minutes to about 28 minutes with Dr. Scott Sherr and Dr. Mercola on GABA deficiency. Includes discussion on SSRIs, serotonin, depression, anxiety, insomnia and low GABA.