www.DrDavisInfiniteHealth.com The process begins with elimination of all wheat and grains, as the gliadin protein of wheat and related proteins of other grains provide the initiating cause of many, if not most, autoimmune diseases.
[SAMA] Episode 58: Morley Robbins, Discover the Root Cause of Autoimmune Diseases.
Unregulated iron build up from lack of a.) bioavailable copper and b.) retinol (vitamin A) to activate the copper enzyme ferroxidase (ceruloplasmin protein with ferroxidase enzyme function). The iron-recycling system slows or stops. This causes inflammatory chaos which displays as autoimmune disease. ~ Nancy Andrews at Duke, Rebecca King at Mayo, Mariann Wesley Resnick at Harvard.
Excerpts: [11:00 minutes] ...let's talk about the iron recycling program in the body, and then we'll talk about autoimmune and then we'll talk about Crohn's [example autoimmune disease]. I want people to understand there is a sequence here...
~ Morley Robbins Copper-Iron Metabolism
We all have a daily iron requirement...somewhere around 25 milligrams are needed a day to make enough red blood cells...It's not a lot. But 95% is supposed to come from a recycling program, called the reticulo-endothelial system...And 5%, that 1 milligram is supposed to come from our diet. That is not what is happening today. People think they are supposed to eat 25 milligrams of iron a day because they don't know that their recycling program is very important.
And what enables the recycling program to work is a copper enzyme called ferroxidase. And it's one of the most important enzymes in the human body. [complex 4 explanation]...When there is not sufficient [bioavailable] copper in our diet, and when there is not sufficient real vitamin A [retinol]. And retinol is very different than beta-carotene...When the body is not able to make adequate levels of ferroxidase, the [iron] recycling system starts to slow down...And what leading researchers are beginning to converge on is that autoimmune conditions are the result of macrophages filling up with iron and they can't release it.
What is a macrophage? That is the professional pack-man in the body that gobbles up pathogens, but it also gobbles up dying red blood cells...what's inside that red blood cell? There's a lot of iron in there. So if that iron gets stuck inside the macrophage it's very destructive and disruptive to the tissue. Well, there are macrophages all over the body.
There are macrophages in our gut. What is happening is there is a build up of iron in the tissue and in these macrophages...People with Crohn's have a build up of iron that is causing an inflammatory process to take place. And they've got all sorts of leaky gut, all sorts of inflammatory processes... One of the biggest break downs is [in] the layer of cells in the inner side of the gut lumen made of epithelial cells. That epithelium is regulated by retinol. Retinol is a powerhouse nutrient....eggs, heavy cream, beef liver, cod liver oil are very rich souces of this essential nutrient.
[19:00 minutes] There are about anywhere from 30 to 100 autoimmune conditions and again, as I said, the leading researchers are converging on this concept of iron laden macrophages. Again, this is not my idea.
This is the work of Nancy Andrews, former dean of the medical school at Duke University, Rebecca King who is a noted pathologist at Mayo Clinic and Mariann Wesley Resnick who is a noted bio-chemist and geneticist at Harvard School of Public Health. So these three women have converged on this theory that these iron laden macrophages are causing this unbelievable tsunami of chaos in peoples bodies.
~ Morley Robbins, Copper-Iron Metabolism
There is much, much more in the podcast above.